The Hypophosphatasia (HPP) is a rare genetic disease caused by mutations in the ALPL gene. It is a metabolic disorder that effects multiple body systems and leads to life-threatening complications. This disease leads to abnormal development of the bones due to defective bone mineralization and can lead to rickets, tempering of the bones that result in different types of bone abnormalities.
The sign and symptoms include soft bones, hypercalcemia, short stature and weak bones with loss of mobility, and may also result in premature death. According to U.S. Food and Drug Administration, it is estimated that in about 100,000 newborns, one suffers severe hypophosphatasia.
The mildest form of hypophosphatasia is called odontohypophosphatasia and is affects teeth. Infantile and perinatal hypophosphatasia is an autosomal recessive disease.
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The global Infantile and Juvenile-onset Hypophosphatasia Treatment market is segmented on basis of treatment type, end user and geography-
Segment by Treatment Type
- Supportive Care
- Enzyme Replacement Therapy
Segment by End User
- Hospitals
- Specialty Clinics
- Clinical Research Organizations
- Others
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On the basis of end user, the global infantile and juvenile-onset hypophosphatasia treatment market is segmented into hospital, clinics, clinical research organizations and others. Rise in patient population of hypophosphatasia, increased awareness and new product/therapy launch is said to drive the global Infantile and Juvenile-onset hypophosphatasia treatment market during the forecast period.
Whereas inadequate access to health care, cost and availability of essential medicines and lack of standardized tools for diagnosis and treatment will hamper the growth of global infantile and juvenile-onset hypophosphatasia treatment market.
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By Geography, the global Infantile and juvenile-onset hypophosphatasia treatment market is segmented into five broad regions viz. North America, Latin America, Europe, Asia-Pacific, and the Middle East & Africa. North America is estimated to lead the global Infantile and Juvenile-onset Hypophosphatasia Treatment market due to rise in cases of hypophosphatasia in United States, Europe market is also projected to experience high growth in the near future.
Asia Pacific market is anticipated to grow at the fastest growth rate during the forecast period, owing to factors such as rising standard of living, lifestyle changes, rise in research and development, government initiatives, drug designations such as breakthrough therapy, Orphan drug designation by FDA helps company to work collaboratively with sponsors to expedite the drug development process.
Some of the major players in global Infantile and Juvenile-onset Hypophosphatasia Treatment market are Alexion Pharmaceuticals Inc., Novartis A.G, and Others.
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