Cholinesterase Activity Testing Market: Introduction
Exposure to pesticides may occur through inhalation, ingestion or absorption through skin. For the assessment of pesticide poisoning doctors recommend the cholinesterase activity testing. Choline esterase is an enzyme that is required for the functioning of the nervous system.
It is responsible for the breakdown of the acetylcholine, so as to stop the overstimulation of the post-synaptic nerve. The failure of breakdown of acetylcholine may be associated with either poisoning by pesticides or by genetic factors. The cholinesterase activity testing is conducted on a few ml of blood.
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The activity may be measured either in the plasma or the RBC or both. Plasma cholinesterase activating testing is generally preferred for acute exposure and the red cell cholinesterase activity testing is most useful for long term exposure.
The level of cholinesterase activity varies greatly from person to person. Thus the cholinesterase activity testing is generally conducted in a person before and after exposure. The cholinesterase activity testing results are expressed in the form of a percentage drop with respect to the base line.
A drop of over 35% is indicative towards severe poisoning. In cases of deliberate poisoning, the cholinesterase activity testing is low enough for the diagnosis without a baseline.
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Cholinesterase Activity Testing Market: Drivers and Restraints
Rise in use of pesticides, increasing research on forensic sciences, rise in awareness regarding environmental factors affecting health are some of the factors that drive the growth of the cholinesterase activity testing market. Another important factor for the rise in growth of the cholinesterase activity testing is the rising prevalence of genetic disorders that affect the activity of the cholinesterase.
However factors such as need for baseline optimization, cost of cholinesterase activity testing may negatively impact the growth of the cholinesterase activity testing market through the forecast period.
Cholinesterase Activity Testing Market: Overview
There are two basic types of cholinesterase activity testing kits available in the market. These are colorimetric and fluorescent ELISA based testing kits. The product type segment is categorized based on the same technology used for the cholinesterase testing kits.
Based on application the type of sample is selected for the cholinesterase activity testing. In generally acute exposure is generally carried out on plasma sample and long term exposure is tested on RBC sample. Some of the end users include hospitals, diagnostic centers, academic and research institutes and forensic laboratories.
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